DBCO-Dap(m-PEG4)-Val-Ala-PAB(m-PEG8)-MMAE Size:10mg 67 SMILES CC1=C(SC=N1)C1=CC=C(CNC(=O)[C@@H]2C[C@@H](O)CN2C(=O)[C@@H](NC(=O)CCCN=[N+]=[N-])C(C)(C)C)C=C1 Purity (HPLC)

67 SMILES CC1=C(SC=N1)C1=CC=C(CNC(=O)[C@@H]2C[C@@H](O)CN2C(=O)[C@@H](NC(=O)CCCN=[N+]=[N-])C(C)(C)C)C=C1 Purity (HPLC) >= 95% Shipping Conditions Room temperature Storage Conditions Refrigerated Shelf Life 12 months after the date of delivery Regulatory Statement For Research Use Only

S)-AHPC-acetamido-O-C2-azide Synonyms CAS Number 2101200-09-1 Related CAS Molecular Formula C26H35N7O5S Molecular Weight 557

445 SMILES OCCCCCCNC(=O)COC1=C2C(=O)N(C3CCC(=O)NC3=O)C(=O)C2=CC=C1 Purity (HPLC) >= 95% Shipping Conditions Room temperature Storage Conditions Refrigerated Shelf Life 12 months after the date of delivery Regulatory Statement For Research Use Only

VHL-CLIP-5C is a CLIP PROteolysis TArgeting Chimera (CLIP-PROTAC)

109 Purity (HPLC) >= 95% Solubility DMSO

DBCO-Dap(m-PEG4)-Val-Ala-PAB(m-PEG8)-MMAE Size:10mg 67 SMILES CC1=C(SC=N1)C1=CC=C(CNC(=O)[C@@H]2C[C@@H](O)CN2C(=O)[C@@H](NC(=O)CCCN=[N+]=[N-])C(C)(C)C)C=C1 Purity (HPLC)SOLU KNEX cleavable linker features a Val Ala dipeptide. In this product, a DBCO Dap(m PEG4) moiety replaces the conventional maleimidocaproyl (MC) unit to enhance aqueous solubility. DBCO is a strained alkyne commonly used in copper free click chemistry, specifically in the strain promoted azide alkyne cycloaddition (SPAAC) reaction. Additionally, m PEG8 is attached to the commonly used self immolative para aminobenzyl (PAB) moiety to further