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Product Name Phthalimidinoglutarimide-propargyl-C1-OH Synonyms Phthalimidinoglutarimide-4'-propargyl-C1-OH CAS Number 2207541-23-7 Related CAS Molecular Formula C17H16N2O4 Molecular Weight 312
HaXS8 bridges HaloTag and SNAP-tag fusion proteins by reacting covalently with their respective active sites: the chloroalkane binds irreversibly to HaloTag’s modified dehalogenase pocket
By combining P1 and P18
and a C-terminal 7-Amino-4-methylcoumarin (AMC) moiety
bioorthogonality
Mal-Propionyl-Beta-Ala-Val-Ala-PAB(m-PEG8)-MMAE gly Product Name Phthalimidinoglutarimide-propargyl-C1-OH Synonyms Phthalimidinoglutarimide-4'-propargyl-C1-OHSOLU KNEX cleavable linker features a Val Ala dipeptide. In this product, m PEG8 is attached to the commonly used self immolative para aminobenzyl (PAB) moiety to increase aqueous solubility. The payload is monomethyl auristatin E (MMAE), a highly potent antimitotic agent that inhibits tubulin polymerization, leading to cell cycle arrest and subsequent apoptosis. Derived from established ADC linker architectures, SOLU KNEX ADC linkers integrate
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