Propargyl-Acetyl-Gly-Gly-Phe-Gly-PAB(m-PEG8)-MMAE Size:10mg CC1=C(SC=N1)C1=CC=C(CNC(=O)[C@@H]2C[C@@H](O)CN2C(=O)[C@@H](NC(=O)CCCN)C(C)(C)C)C=C1 Purity (HPLC) >= 95%

CC1=C(SC=N1)C1=CC=C(CNC(=O)[C@@H]2C[C@@H](O)CN2C(=O)[C@@H](NC(=O)CCCN)C(C)(C)C)C=C1 Purity (HPLC) >= 95% Shipping Conditions Room temperature Storage Conditions Refrigerated Shelf Life 12 months after the date of delivery Regulatory Statement For Research Use Only

Molecular Glues for Targeted Protein Degradation: From Serendipity to Rational Discovery

Product Name MaP555-Maleimide Synonyms CAS Number n/a Related CAS Molecular Formula C33H34N6O7S Molecular Weight 658

182 SMILES [2H]C([2H])([2H])OC1=CC=C(C)C(=C1)N(=O)=O Purity (HPLC) >= 95% Shipping Conditions Room temperature Storage Conditions Refrigerated Shelf Life 12 months after the date of delivery Regulatory Statement For Research Use Only

Product Name BG-SS-SulfoCy5 Synonyms SNAP-SS-SulfoCynine 5 CAS Number Related CAS Molecular Formula C51H61N9O8S4 Molecular Weight 1056

Propargyl-Acetyl-Gly-Gly-Phe-Gly-PAB(m-PEG8)-MMAE Size:10mg CC1=C(SC=N1)C1=CC=C(CNC(=O)[C@@H]2C[C@@H](O)CN2C(=O)[C@@H](NC(=O)CCCN)C(C)(C)C)C=C1 Purity (HPLC) >= 95%SOLU KNEX cleavable linker features a Gly Gly Phe Gly (GGFG) peptide. m PEG8 is attached to the commonly used self immolative para aminobenzyl (PAB) moiety to increase aqueous solubility. The payload is monomethyl auristatin E (MMAE), a highly potent antimitotic agent that inhibits tubulin polymerization, leading to cell cycle arrest and subsequent apoptosis. Derived from established ADC linker architectures, SOLU KNEX ADC linkers integrate