NRX-252114 Size:5mg Contains an E3 ligase ligand

Contains an E3 ligase ligand with alkyl linker and terminal amine

33 SMILES OCCCC1=C2CN(C3CCC(=O)NC3=O)C(=O)C2=CC=C1 Purity (HPLC) >= 95% Shipping Conditions Room temperature Storage Conditions Refrigerated Shelf Life 12 months after the date of delivery Regulatory Statement For Research Use Only

S)-AHPC-CO-C4-NH2 HCl Synonyms CAS Number 2245697-83-8 Related CAS 2138439-53-7 (free base) Molecular Formula C27H41Cl2N5O4S Molecular Weight 602

074 SMILES CC(C)(C)OC(=O)CN1CCN(CC(=O)NCCOCCOCCOCCOCCOCC#C)CCN(CC(=O)OC(C)(C)C)CCN(CC(=O)OC(C)(C)C)CC1 Purity (HPLC) >= 95% Shipping Conditions Room temperature Storage Conditions Refrigerated Shelf Life 12 months after the date of delivery Regulatory Statement For Research Use Only

Cancer Research 2017

NRX-252114 Size:5mg Contains an E3 ligase ligandNRX 252114 is an enhancer of the interaction between beta catenin and beta TrCP. NRX 252114 acts as molecular glue in cells to promote the ubiquitylation and subsequent degradation of mutantbeta catenin by the 26S proteasome. Product Name NRX 252114 Synonyms CAS Number 2763260 39 3 Related CAS Molecular Formula C22H12Cl2F3N3O2S Molecular Weight 510. 31 SMILES FC(F)(F)C1=CC(SC2=C(Cl)C=CC=C2Cl)=C(C(=O)N2CC3=CC=CC(C#N)=C3C2)C(=O)N1 Purity (HPLC) >= 95%