P18h (AggFluor Halotag Ligand) Size:100nmol 6 SMILES [2H]C([2H])([2H])OC1=C(Cl)C=C(C=C1)N(=O)=O Purity (HPLC)

6 SMILES [2H]C([2H])([2H])OC1=C(Cl)C=C(C=C1)N(=O)=O Purity (HPLC) >= 95% Shipping Conditions Room temperature Storage Conditions Refrigerated Shelf Life 12 months after the date of delivery Regulatory Statement For Research Use Only

NCCOCCOC1=C2C(=O)N(C3CCC(=O)NC3=O)C(=O)C2=CC=C1 Purity (HPLC) >= 95% Shipping Conditions Room temperature Storage Conditions Refrigerated Shelf Life 12 months after the date of delivery Regulatory Statement For Research Use Only

632 SMILES O=C1N(CC2=C(NCCOCCOCCOCCOCCOCCOCC#C)C=CC=C12)C1CCC(=O)NC1=O Purity (HPLC) >= 95% Shipping Conditions Room temperature Storage Conditions Refrigerated Shelf Life 12 months after the date of delivery Regulatory Statement For Research Use Only

Abstract S6-04: The PI3K inhibitor

684 SMILES: CN(C)C1=CC=C2C(OC3=CC(C=CC3=C2C2=CC=C(C=C2C([O-])=O)C(=O)NCCOCCOCCOCC#C)=[N+](C)C)=C1

P18h (AggFluor Halotag Ligand) Size:100nmol 6 SMILES [2H]C([2H])([2H])OC1=C(Cl)C=C(C=C1)N(=O)=O Purity (HPLC)P18h is a HaloTag ligand incorporating the fluorogenic AggFluor P18 dye. AggFluor is derived from the synthetic GFP chromophore, 4 hydroxybenzylidene imidazolinone (HBI), and belongs to the class of molecular rotor fluorophores widely used in biological imaging due to their sensitivity to environmental factors such as viscosity. When bound to properly folded proteins, AggFluors are quenched and remain non fluorescent; however, protein misfolding or