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DBCO-Propionyl-Val-Ala-PAB(m-PEG8)-Exatecan Size:10mg 532 Purity (HPLC) >= 95%

SKU 60201700967
4.5
USD445.00 USD489.00

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Description

532 Purity (HPLC) >= 95% Solubility DMSO

Product Name CA-Alexa Fluor 488 Synonyms Alexa Fluor 488-Halo

Fitzgibbons

Haegebarth

It has been used as a fluorescent substrate/probe to study the distribution and mechanism of action of multidrug resistance-associated protein 2 (Mrp2)

DBCO-Propionyl-Val-Ala-PAB(m-PEG8)-Exatecan Size:10mg 532 Purity (HPLC) >= 95%SOLU KNEX cleavable linker features a Val Ala dipeptide. m PEG8 is attached to the commonly used self immolative para aminobenzyl (PAB) moiety to increase aqueous solubility. The payload is Exatecan, a highly potent topoisomerase I inhibitor derived from camptothecin, which induces DNA damage by stabilizing the topoisomerase IDNA complex, resulting in cell cycle arrest and apoptosis. Derived from established ADC linker architectures, SOLU KNEX ADC

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