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Product Name Pomalidomide-PEG2-C2-amine HCl Synonyms Pomalidomide-4'-PEG2-C2-amine HCl CAS Number 2245697-87-2 Related CAS 2093416-32-9 (free base) Molecular Formula C19H25ClN4O6 Molecular Weight 440
Broichhagen
Nature 2020
Degrader building block for targeted protein degradation
by coordinating through its four nitrogens and four carboxylate oxygen atoms
Mal-Acetyl-Dap(m-PEG4)-Val-Ala-PAB(m-PEG8)-PNP 5' Product Name Pomalidomide-PEG2-C2-amine HCl SynonymsSOLU KNEX cleavable linker features a Val Ala dipeptide. In this product, a Mal Acetyl Dap(m PEG4) moiety replaces the conventional maleimidocaproyl (MC) unit to enhance aqueous solubility. The Mal Acetyl group may also improve retro Michael addition stability during antibody conjugation. Additionally, m PEG8 is attached to the commonly used self immolative para aminobenzyl (PAB) moiety to further increase aqueous solubility. The PNP (para
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